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RESEARCH

ST GEORGHE CANCER CENTRE RESEARCH

A number of promising areas of research into cancer are in progress at the St George Cancer Centre.Research includes:

  •  Investigation of the ways prostate & ovarian cancer metastasise (spread),  and the drug and radio-resistance associated with tumour micro-environments, and cancer stem cell (CSC ) & epithelial cell changes.
  • Investigation of ‘novel biomarkers’ in human body fluids, looking for markers that may indicate cancer. This work offers hope of new methods of early diagnosis, so critical in many cancers where the symptoms only become known when it’s too late.

The aim is to develop targeted and combination cancer therapies to control micro-metastatic prostate, breast and ovarian cancers. The work has application for other similar cancers as well.

Targeted therapies

mean that patients are likely to live longer and with a higher quality of life,
as the treatments have less risk, less side effects and a greater impact on the cancer.

PUBLISHED

RESEARCH

Acquisition of epithelial-mesenchymal transition and cancer stem cell phenotypes is associated with activation of the PI3K/Akt/mTOR pathway in prostate cancer radioresistance Cell Death and Disease

L Chang, P Graham, J Hao, J Ni, J Bucci, PJ Cozzi, JH Kearsley & Y Li (2013)

Epithelial cell adhesion molecule (EpCAM) is associated with prostatecancer metastasis and chemo/radioresistance

Jie Ni, PaulCozzi, Jingli Hao, Julia Beretov, Lei Chang, Wei Duan, Sarah Shigdar, Warick Delprado, Peter Graham, Joseph Bucci, John Kearsley, Yong Li; International Journal of Biochemistry & Cell Biology (2013)

CD44 Variant 6 is Associated With Prostate Cancer Metastasis andChemo-/Radioresistance

Jie Ni, Paul J. Cozzi, Jing L. Hao,Julia Beretov, Lei Chang, Wei Duan, Sarah Shigdar, Warick J. Delprado, Peter H. Graham, Joseph Bucci, John H. Kearsley, and Yong Li; The Prostate (2014)

Cancer Stem Cells in Prostate Cancer Chemoresistance Current Cancer Drug Targets

Jie Ni, Paul Cozzi, Jingli Hao, Wei Duan, Peter Graham, John Kearsley and Yong Li (2014)

Cancer Stem Cells “The Root of Radioresistance” in Prostate Cancer Radiotherapy World Journal of Cancer Research

Yong Li, Paul Cozzi, Peter Graham, Joseph Bucci, and John Kearsley (2013)

Targeting PI3K/Akt/mTOR signaling pathway in the treatment of prostate cancer radioresistance Crit Rev Oncol/Hematol

Lei Changa, Peter H. Grahama, Jie Nia, Jingli Haoa, Joseph Buccia, Paul J. Cozzib, Yong Lia (2015)

Epithelial cell adhesion molecule (EpCAM) is involved in prostate cancer chemotherapy/radiotherapy response in vivo

Jie Ni, Paul Cozzi, Julia Beretov, Wei Duan, Joseph Bucci, Peter Graham and Yong Li (2018)

Liquid biopsy in ovarian cancer: recent advances in circulating extracellular vesicle detection for early diagnosis and monitoring progression

Lei Chang1, Jie Ni, Ying Zhu, Bairen Pang, Peter Graham, Hao Zhang, Yong Li (2019)

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